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M9480655.TXT
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1994-08-20
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Document 0655
DOCN M9480655
TI [A new prophylactic agent in AIDS: Ansatipine. Disseminated
Mycobacterium avium complex infection is now the most frequent of the
opportunistic bacterial infections in AIDS]
DT 9410
AU Dautzenberg B; Service des Maladies Respiratoires, Groupe Hospitalier
Pitie-; Salpetriere, Paris.
SO Allerg Immunol (Paris). 1994 Apr;26(4):141-4. Unique Identifier :
AIDSLINE MED/94304496
AB Otherwise infrequent, infections by non-tuberculous or atypical
mycobacteria are now rising in AIDS. Infection with the Mycobacterium
avium complex (MAC) is now the most frequent opportunistic bacterial
infection, because of better detection of HIV positive patients. The
incidence, which is probably underestimated, is now 14-33% in France.
The Mycobacterium avium complex is responsible for 96% of infections by
atypical mycobacteria in AIDS patients. Diagnosis of infection by MAC is
bacteriological. The clinical picture is non-specific and associates
high fever, profuse sweating, weight loss and asthenia, all of which
make a severe alteration to the general condition. This infection
persists in AIDS patients to a late phase of evolution where
Immunodeficiency is profound, that is when the level of CD4 lymphocytes
is low. Because of this, it is an increasing and preoccupying problem in
patients, since it involves the prognosis of life. This shows the
importance of prophylactic treatment for this pathology.
DE AIDS-Related Opportunistic Infections/*EPIDEMIOLOGY/MICROBIOLOGY/
PREVENTION & CONTROL English Abstract France/EPIDEMIOLOGY Human
Incidence Mycobacterium avium-intracellulare Infection/*EPIDEMIOLOGY/
PREVENTION & CONTROL Rifabutin/*THERAPEUTIC USE United
States/EPIDEMIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).